Category Archives: Obesity

Obesity-Inflammation Related; Common Thread with Diseases Part 3

For the past couple of weeks we have published articles on obesity and Michael Glade’s belief that inflammation, as the result of poor diet, environmental factors, and others is the primary cause of obesity.  People who are high is visceral fat have a high risk of developing metabolic syndrome, prediabetes, and diabetes. 

University of California, San Diego School of Medicine researchers “discovered that inflammation provoked by immune cells called macrophages leads to insulin resistance and Type 2 diabetes. Macrophages, found in white blood cells in the bone marrow, are key players in the immune response. When these immune cells get into tissues, such as adipose (fat) or liver tissue, they release cytokines, which are chemical messenger molecules used by immune and nerve cells to communicate. These cytokines cause the neighboring liver, muscle or fat cells to become insulin resistant, which in turn can lead to Type 2 diabetes. The hope is to block or disarm the macrophage inflammatory pathway to interrupt the cascade that leads to insulin resistance and diabetes. A small molecule compound to block JNK1 could prove a potent insulin-sensitizing, anti-diabetic agent. The research also proved that obesity without inflammation does not result in insulin resistance. Olefsky, researcher, explained that when an animal or a human being becomes obese, they develop steatosis, or increased fat in the liver. The steatosis leads to liver inflammation and hepatic insulin resistance.” ScienceDaily (Nov. 7, 2007)”  See this article in it’s entirety at http://www.sciencedaily.com/releases/2007/11/071106133106.htm

Of interest, the National Center for Complementary & Alternative Medicine (NCCAM)  has the following clinical trial posted on its website.  I was disappointed to see the study fell short of criteria which might further substantiate Dr. Glade’s position or lead to a broader study.  Six weeks is hardly enough time for a fair assessment of any meaningful conclusion regarding long term effects of inflammation.  I also found it interesting that fish oils were not included nor excluded since they are recognized to influence inflammation and immune system markers. The low number of participants does not represent the population adequately, either. Hopefully, this is just an initial step in a broader study that will change the way we approach the subject of inflammation and metabolic syndrome and diabetes II. 

 Recruiting -verified and sponsored  by (NCCAM), May 2008
ClinicalTrials.gov Identifier: NCT00334919 due to be completed in November 2008. ClinicalTrials.gov processed this record on December 19, 2008
RCT of the Naturopathic Anti-Inflammatory Diet
Conditions: Diabetes Mellitus, Type 2;   Prediabetes
Intervention: Behavioral: Diet (Anti-Inflammatory or standard diabetic diet)
Funded By:  NIH
Start Date:  May 2006  Current Status – Phase II
The purpose of the study is to determine which diet is better, the naturopathic Anti-inflammatory Diet or the standard diet based on current ADA (American Diabetes Association) guidelines?
 The primary outcome measures of cytokines for 13 weeks, and secondary outcome measures:
            *Glucose: 113 weeks
            *Weight:13 weeks
            *Lipids: 13 weeks

Estimated Enrollment was 36 .  Details include being on the ADA diet for 5 weeks, then randomized to either ADA or AI for 6 weeks.  Other restrictions apply related to the diet as well as looking at blood markers that show how the immune system responds to the different diets. The expectation is the AI will result in less inflammation and a better response by the immune system than the ADA diet as well as looking at the effects of lipids and glucose. Levels of blood lipids and glucose will be considered to evaluate any effects.  Of course, appropriate inclusion criteria related to diabetes is listed and the following exclusion criteria.

 *Current major debilitating mental or physical illness that would interfere  with participation (as determined by the participant’s medical history)
*Taking diabetic medication other than sulfonylurea
*Taking Gymnema silvestra (a naturopathic diabetes treatment)
*Taking medications that have anti-inflammatory affects (lipid lowering agents,   NSAIDS, COX 2 inhibitors, aspirin, HRT, oral contraceptives, testosterone, seizure medications)
*Taking weight loss medications
*Severe renal, hepatic, or heart disease
*Triglycerides >500 mg/dL
*Bulimia
*Pregnancy or lactation
*Current excessive use of alcohol
Current/recent chronic use of recreational drugs
Smoker
More than 4 hours/week of aerobic exercise
Have gained or lost more than 15 pounds during previous 6 months
Planning on moving out of the area in the next 4 months
Is a participant in another medical research study
Is following a weight loss diet
Is unwilling to accept random assignment of the experimental diets
Food preferences and/or allergies that will interfere with consumption of experimental medications
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Obesity-Inflammation Related-Common Thread with Diseases-Part 2

 We continue from last week’s Part 1 with Michael Glade and his insights into obesity as it relates to the inflammation process.  A quick overview is two types of fat are present in the body: subcutaneous and visceral. Subcutaneous fat is the type found just underneath the skin, which may cause dimpling and cellulite. Visceral fat, on the other hand, is located in the abdomen and surrounding vital organs. It can infiltrate the liver and other organs, streak through your muscles and even strangle your heart; and turns out you can have it even if you appear to be thin.  It is the latter, visceral, fat that is linked to many other diseases, everything from bad cholesterol and hypertension to diabetes, heart disease and stroke. Dr. Glade believes at the core of the problem is the issue of inflammation.  Please refer to that article as we will continue here where we left off.

Break down of fatty acids in an abnormal fashion causes an inflammatory load which does unhealthy things to body tissue. If you expose cartilage, cancer, arthritic tissue to a specific signal of inflammation called alpha, they will always respond as if they are under attack.  Chronically exposed poor dietary input can cause or predispose a downward spiral in the body upset.  For example, the problem may be a missing array of essential fatty acids.  Over nutrition seems to be a problem and not sufficient oils or anti-inflammatory products.  If the body can stabilize with eating right, exercise, not smoking or drinking, then the body becomes more stable. 

With a wound you would expect a short term inflammation situation which is a good thing.  The brain is just like other tissue.  We need to replace at least at the same pace as old stuff carrying off. The human brain also experiences changes related to inflammatory factors.  The brain wants to heal with growth of new neurons, a normal response of learning that deals with activity where they grow and dispose of old stuff. 

 Conventional approaches to control of body fat includes weight loss and exercise.  MRI can identify the infiltration of visceral fat around and in specific tissue, but Michael Glade suggests the use of a laboratory test called C Reactive Protein (CRP) to get some inkling that inflammation is present.  There may be a balance between CRP and the oil EPA (Eicosapentaenoic Acid).  Normal  ranges are tested with a group of norms which may be difficult to identify.  What is normal within a group since the control group could represent those in the elevated portion of the population?  We just don’t know. (A test we may use is a genetic test which identifies inflammation from a hereditary factor, particularly when trying to decide if the influence may be environmental rather than hereditary.)

 One of the markers for longevity is control of abdominal fat which is identified as the visceral load.  An inflammation marker is a practical approach of getting the belly fat down.  The dual nature of obesity is that if there is an imbalance in the body, then there is going to be an unintended consequence.  The goal needs to be met to control and modify abdominal fat load. 

A few of the suggestions he gives are as follows:

*Our food supplies have become disconnected from nature.

*Learned failure is when you change lifestyle and then over-exercise. If the patient losses 10 pounds but hurts and is fatigued from over exercising,  they will have an excuse to not stay the course.

*When failure of weight loss occurred due to calorie restriction becoming very aggressive with omega 3 fats using  3-5 tablespoons of flax or fish oil would give good results.  The body wouldn’t change weight but it would reshape.

*Efficiently operating digestive tract is important.

*Activity needs to be increased.  Failures often are because activity isn’t high enough.

*Cause is heightened inflammation- imbalance can be tipped either way and neither may be the most beneficial.

*Anti-inflammatory medications often are mild poisons that push the body back into less inflammation-Dr. Glade questions if this is a good thing.

*Structural fats do very important replacement of fatty acid membranes.

* Use omega oils generally for inflammatory condition.  These are not generally stored or used in the body as caloric intake as the fundamental function of fatty acids in many ways is to restore balance.  They don’t suppress or stimulate inflammation.  Balancing inflammation is what they do and are essentially not drug like, they don’t turn off signals.  

*Suggested Ratio EPA:DHA  EPA 3,000 mg of product  4,000 mg DHA to renormalize triglycerides in the system.  This information is recognized by the drug industry.

Other products:

*Diet: avoid process starches and fatty acid meat and increase fruit and veggies.

* Development of brain is dependent upon DHA and is not found in most any place other than fish. 

* Berries, diversifying your response system is appealing.Recommended are 10 servings of fruit and vegetables per day. Salads are encouraged before meals.

* Starchy vegetables are off the menu. 

*Manganese, selenium, and other trace minerals can only come from our soil.  We are at a point of having to resort to food supplements.  Even if the soil is fortified, the soil is exhausted.  Consequently, trace mineral supplements are absolutely essential.

    – Selenium 100 mcg-anti cancer effective-balance with iodine

     – Chromium 1,000 mcg for sugar regulation of the body

*Boron 2 mg- places a role in digestion -good for inflammation in digestive tract and central nervous system

*Carnatine and acetyl-carnatine- heart and skeletal-less free-radical production

*Co-Q10 increases efficiency of fat burning and make systems more efficient-less free radical production resulting in feeling and moving better. 

Calcium-drop dairy because it causes inflammation-calcium supplement, vitamin D- Take optimum dose over 5-6 times per day for absorption.

Dr. Glade notes slim people fidget 2-3 hours more times per day and are always moving.

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Obesity-Inflammation Related; Common Thread with Diseases Part 1

Obesity is thought to be a disease of inflammation, according to Michael Glade, Ph.D. 

I became acquainted with his work through a DVD given to me by NeuroScience.  We have use NeuroScience protocols with great success; a company that focuses on “Target Amino Acids” as a means to address healing of the adrenal gland and balance neurotransmitters for the treatment of many symptoms including anxiety, sleep maintenance and insomnia, depression, and memory loss.

Dr. Glade is a Certified Nutritional Specialist (CNS) with degrees from the Massachusetts Institute of Technology (MIT) and Cornell University and teaching and research experience at Rutgers University, the University of Maryland, Northwestern University and at the Nutrition Institute of the University of Bridgeport. [1] 

Dr. Glade contends that when a patient has obesity for 5 years or more, the cellular mechanism is disrupted and regulation is thrown off through nutritional and other influences.  Cancer, arthritis, allergy, digestive literature look for a common thread which is traditionally separate in peoples minds as separate diseases, but it is looking more and more that they are individual symptoms manifested in an individual similarly condition.  It starts with people who eat improperly and once the  condition of unregulated inflammation develops, then under that umbrella,  one could end up with all the listed above common disease.

Insulin resistance falls under this umbrella where something goes arye in the metabolism of glucose within muscle cells.  People don’t get better, they get worse.  It doesn’t cure or arrest with the use of any existing medications. Control of diabetes II and insulin is not cured or suppressed by any existing treatment medications.  The premise is that people who have insulin resistance will slowly but surely deteriorate.  Dr. Glade believes there is something missing in that model.  We are treating a blood level of insulin but not the disease. He suggests that something, possibly environmental is the missing piece.

Research suggest abdominal fat in the visceral organ (around organs inside) appears to be genetically different from much of the than other fat in the body.  It is the most insulin responsive part of the body. In insulin resistance patients, the insulin is not responsive on the muscle whereas the belly fat stores is over reactive and sucks the insulin up.  The degree of hypersensitive reflects as the more inflamed they become.  The more inflamed they are the more tendencies they have to over-store abdominal fat.

Insulin control in the pancreas is disturbed when the body is carrying a high amount of an inflammatory formed, abnormal cytokine molecules produced by the body so one part of the body can communicate with another part. Overreactions throughout the body because of  lifestyle, environment, diet, result in tissue not normally responsive, but will then activate due to an overexposure of inflammation.  This will force the organ to over-respond.  This condition is not well monitored or regulated in the body.  The blood has an almost unlimited capacity to carry these inflammatory molecules in the body.  This response is what needs to be brought under control and can only be accomplished by improved lifestyle, environmental factors, detoxification, and a healthy diet.

Part 2 will address what can be done about this dynamic problem.

[1]Dr. Michael Glade emphasizes  specific dietary plans and supplement protocols, especially in programs targeted at brain function, weight reduction, smoking cessation, and life extension for the terminally ill.  Dr. Glade lectures extensively across the US and Europe. Dr. Glade is a noted researcher who is deeply appreciated in the nutritional and scientific communities for providing a significant body of peer-reviewed substantiation for multiple health claims that have been approved by the FDA.