Category Archives: Nutritional Therapies

Obesity-Inflammation Related; Common Thread with Diseases Part 3

For the past couple of weeks we have published articles on obesity and Michael Glade’s belief that inflammation, as the result of poor diet, environmental factors, and others is the primary cause of obesity.  People who are high is visceral fat have a high risk of developing metabolic syndrome, prediabetes, and diabetes. 

University of California, San Diego School of Medicine researchers “discovered that inflammation provoked by immune cells called macrophages leads to insulin resistance and Type 2 diabetes. Macrophages, found in white blood cells in the bone marrow, are key players in the immune response. When these immune cells get into tissues, such as adipose (fat) or liver tissue, they release cytokines, which are chemical messenger molecules used by immune and nerve cells to communicate. These cytokines cause the neighboring liver, muscle or fat cells to become insulin resistant, which in turn can lead to Type 2 diabetes. The hope is to block or disarm the macrophage inflammatory pathway to interrupt the cascade that leads to insulin resistance and diabetes. A small molecule compound to block JNK1 could prove a potent insulin-sensitizing, anti-diabetic agent. The research also proved that obesity without inflammation does not result in insulin resistance. Olefsky, researcher, explained that when an animal or a human being becomes obese, they develop steatosis, or increased fat in the liver. The steatosis leads to liver inflammation and hepatic insulin resistance.” ScienceDaily (Nov. 7, 2007)”  See this article in it’s entirety at http://www.sciencedaily.com/releases/2007/11/071106133106.htm

Of interest, the National Center for Complementary & Alternative Medicine (NCCAM)  has the following clinical trial posted on its website.  I was disappointed to see the study fell short of criteria which might further substantiate Dr. Glade’s position or lead to a broader study.  Six weeks is hardly enough time for a fair assessment of any meaningful conclusion regarding long term effects of inflammation.  I also found it interesting that fish oils were not included nor excluded since they are recognized to influence inflammation and immune system markers. The low number of participants does not represent the population adequately, either. Hopefully, this is just an initial step in a broader study that will change the way we approach the subject of inflammation and metabolic syndrome and diabetes II. 

 Recruiting -verified and sponsored  by (NCCAM), May 2008
ClinicalTrials.gov Identifier: NCT00334919 due to be completed in November 2008. ClinicalTrials.gov processed this record on December 19, 2008
RCT of the Naturopathic Anti-Inflammatory Diet
Conditions: Diabetes Mellitus, Type 2;   Prediabetes
Intervention: Behavioral: Diet (Anti-Inflammatory or standard diabetic diet)
Funded By:  NIH
Start Date:  May 2006  Current Status – Phase II
The purpose of the study is to determine which diet is better, the naturopathic Anti-inflammatory Diet or the standard diet based on current ADA (American Diabetes Association) guidelines?
 The primary outcome measures of cytokines for 13 weeks, and secondary outcome measures:
            *Glucose: 113 weeks
            *Weight:13 weeks
            *Lipids: 13 weeks

Estimated Enrollment was 36 .  Details include being on the ADA diet for 5 weeks, then randomized to either ADA or AI for 6 weeks.  Other restrictions apply related to the diet as well as looking at blood markers that show how the immune system responds to the different diets. The expectation is the AI will result in less inflammation and a better response by the immune system than the ADA diet as well as looking at the effects of lipids and glucose. Levels of blood lipids and glucose will be considered to evaluate any effects.  Of course, appropriate inclusion criteria related to diabetes is listed and the following exclusion criteria.

 *Current major debilitating mental or physical illness that would interfere  with participation (as determined by the participant’s medical history)
*Taking diabetic medication other than sulfonylurea
*Taking Gymnema silvestra (a naturopathic diabetes treatment)
*Taking medications that have anti-inflammatory affects (lipid lowering agents,   NSAIDS, COX 2 inhibitors, aspirin, HRT, oral contraceptives, testosterone, seizure medications)
*Taking weight loss medications
*Severe renal, hepatic, or heart disease
*Triglycerides >500 mg/dL
*Bulimia
*Pregnancy or lactation
*Current excessive use of alcohol
Current/recent chronic use of recreational drugs
Smoker
More than 4 hours/week of aerobic exercise
Have gained or lost more than 15 pounds during previous 6 months
Planning on moving out of the area in the next 4 months
Is a participant in another medical research study
Is following a weight loss diet
Is unwilling to accept random assignment of the experimental diets
Food preferences and/or allergies that will interfere with consumption of experimental medications
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Obesity-Inflammation Related-Common Thread with Diseases-Part 2

 We continue from last week’s Part 1 with Michael Glade and his insights into obesity as it relates to the inflammation process.  A quick overview is two types of fat are present in the body: subcutaneous and visceral. Subcutaneous fat is the type found just underneath the skin, which may cause dimpling and cellulite. Visceral fat, on the other hand, is located in the abdomen and surrounding vital organs. It can infiltrate the liver and other organs, streak through your muscles and even strangle your heart; and turns out you can have it even if you appear to be thin.  It is the latter, visceral, fat that is linked to many other diseases, everything from bad cholesterol and hypertension to diabetes, heart disease and stroke. Dr. Glade believes at the core of the problem is the issue of inflammation.  Please refer to that article as we will continue here where we left off.

Break down of fatty acids in an abnormal fashion causes an inflammatory load which does unhealthy things to body tissue. If you expose cartilage, cancer, arthritic tissue to a specific signal of inflammation called alpha, they will always respond as if they are under attack.  Chronically exposed poor dietary input can cause or predispose a downward spiral in the body upset.  For example, the problem may be a missing array of essential fatty acids.  Over nutrition seems to be a problem and not sufficient oils or anti-inflammatory products.  If the body can stabilize with eating right, exercise, not smoking or drinking, then the body becomes more stable. 

With a wound you would expect a short term inflammation situation which is a good thing.  The brain is just like other tissue.  We need to replace at least at the same pace as old stuff carrying off. The human brain also experiences changes related to inflammatory factors.  The brain wants to heal with growth of new neurons, a normal response of learning that deals with activity where they grow and dispose of old stuff. 

 Conventional approaches to control of body fat includes weight loss and exercise.  MRI can identify the infiltration of visceral fat around and in specific tissue, but Michael Glade suggests the use of a laboratory test called C Reactive Protein (CRP) to get some inkling that inflammation is present.  There may be a balance between CRP and the oil EPA (Eicosapentaenoic Acid).  Normal  ranges are tested with a group of norms which may be difficult to identify.  What is normal within a group since the control group could represent those in the elevated portion of the population?  We just don’t know. (A test we may use is a genetic test which identifies inflammation from a hereditary factor, particularly when trying to decide if the influence may be environmental rather than hereditary.)

 One of the markers for longevity is control of abdominal fat which is identified as the visceral load.  An inflammation marker is a practical approach of getting the belly fat down.  The dual nature of obesity is that if there is an imbalance in the body, then there is going to be an unintended consequence.  The goal needs to be met to control and modify abdominal fat load. 

A few of the suggestions he gives are as follows:

*Our food supplies have become disconnected from nature.

*Learned failure is when you change lifestyle and then over-exercise. If the patient losses 10 pounds but hurts and is fatigued from over exercising,  they will have an excuse to not stay the course.

*When failure of weight loss occurred due to calorie restriction becoming very aggressive with omega 3 fats using  3-5 tablespoons of flax or fish oil would give good results.  The body wouldn’t change weight but it would reshape.

*Efficiently operating digestive tract is important.

*Activity needs to be increased.  Failures often are because activity isn’t high enough.

*Cause is heightened inflammation- imbalance can be tipped either way and neither may be the most beneficial.

*Anti-inflammatory medications often are mild poisons that push the body back into less inflammation-Dr. Glade questions if this is a good thing.

*Structural fats do very important replacement of fatty acid membranes.

* Use omega oils generally for inflammatory condition.  These are not generally stored or used in the body as caloric intake as the fundamental function of fatty acids in many ways is to restore balance.  They don’t suppress or stimulate inflammation.  Balancing inflammation is what they do and are essentially not drug like, they don’t turn off signals.  

*Suggested Ratio EPA:DHA  EPA 3,000 mg of product  4,000 mg DHA to renormalize triglycerides in the system.  This information is recognized by the drug industry.

Other products:

*Diet: avoid process starches and fatty acid meat and increase fruit and veggies.

* Development of brain is dependent upon DHA and is not found in most any place other than fish. 

* Berries, diversifying your response system is appealing.Recommended are 10 servings of fruit and vegetables per day. Salads are encouraged before meals.

* Starchy vegetables are off the menu. 

*Manganese, selenium, and other trace minerals can only come from our soil.  We are at a point of having to resort to food supplements.  Even if the soil is fortified, the soil is exhausted.  Consequently, trace mineral supplements are absolutely essential.

    – Selenium 100 mcg-anti cancer effective-balance with iodine

     – Chromium 1,000 mcg for sugar regulation of the body

*Boron 2 mg- places a role in digestion -good for inflammation in digestive tract and central nervous system

*Carnatine and acetyl-carnatine- heart and skeletal-less free-radical production

*Co-Q10 increases efficiency of fat burning and make systems more efficient-less free radical production resulting in feeling and moving better. 

Calcium-drop dairy because it causes inflammation-calcium supplement, vitamin D- Take optimum dose over 5-6 times per day for absorption.

Dr. Glade notes slim people fidget 2-3 hours more times per day and are always moving.

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Heavy Metal Burden-Cadmium, Lead, Mercury Plus More

In the toxic environment we live it, it is hard to imagine one being able to escape the potential dangers that threaten us in our air, water and food.  Some believe, as I do, that the health of this nation, evidenced by the escalation of heart disease and chronic acquired diseases, is in direct relationship to the accumulation of the toxins within.  High levels of metals, drugs, and manmade compounds can be found in our environment.
 We hear about the effects of global warming more than we hear about how toxins are dismantling this nation of its richest resource–health.  As stewards of this earth and our bodies, we need to understand the problem and do our part to protect our families, community and self.  We aren’t hopeless or helpless in this age of information unless we choose to be. 

 Heavy metal burden is the unintended consequence of industry worldwide dating back to the Industrial Revolution in the 1700’s.  The economy that was created unquestionably changed the world…and it is still changing our world today.  The cost of healthcare continues to rise and some believe that the collection of heavy metal entities in the body contributes to acute and chronic disease, primary introduced into the body by oral or inhalation means.  Cadmium is the most toxic element to man, then lead, then mercury.   Toxins that are manmade chemicals contribute as well.  Little is considered as people wash with scrubs or work with unprotected hands in harsh chemicals.

The economy of healthcare is found in the treatment of disease.  While an enormous amount of money annually goes to research, the title of drugs is at the top of the lists.  One thing for sure, there is a drug for almost everything.  Illness is sometimes considered a synonym for disease or sometimes viewed as the subjective perception of the patient or an objectively defined disease.  If the objectively defined disease is illusive, then the problem exists only in the mind of the patient. Or does it?  

Environmental doctors and those interested in prevention of disease take a different look at the disease model. First, they consider the patient might be right!  Their symptoms might actually be an underlying cause even thought the cause may be illusive and unrelated to emotional or mental illness.   You don’t have to be a doctor or struck with illness to share wisdom.  It is easier and less expensive to prevent disease than to treat it. 

The alternative doctor looks at the body and sees it wondrously made. Food and nourishment is required to fuel and maintain the machine.  The cleaner sources the food comes from, and the more nutritious the source, the better.   If the body is unable to function properly because of enzyme and nutritional deficiencies, should you add a drug to make the process happen or inhibit another process to provide an artificial balance?  In alternative medicine, the practitioner strives to restore the balance.  Removing a toxin is preferred to adding a drug and reasonable nutritional support including a healthy diet. 

One area of alternative medicine many patients have benefited is detoxification programs including those specifically designed to remove xenobiotics (manmade chemicals including plastics and pesticides) and chelation for heavy metal burden.  A healthy BMI (body mass index) is important because toxins store in fat.  If your attitude reflects little dedication for long term effects of healthy living, then you need read no further.  If you understand investing in your health has long term rewards, then you should consult a trained practitioner in chelation to get the best care.

 For example, some professionals use blood tests but results reflect recent exposures and typically not chronic exposures. Others use hair analysis which typically reflect chronic exposure but not body stores of toxic metals.  Fecal tests can be influenced by dietary and metabolic factors.  Challenge tests may fail to produce an expected response in glutathione deficient patients, provide the best results for elevated and very elevated levels.  The challenge test, with the preferred chelator,  is the preferred test.  Often multiple toxic metals are present and increase the duration of the chelation processEach additional toxic metal lowers the toxic threshold for every other metal resulting over time in dysfunction of multiple organs and tissues, impaired chemical detoxification, excessive free-radical formation, and chronic conditions such as chronic fatigue syndrome and fibromyalgia.  Also, increased oxidative stress, related to elevated heavy metals may precondition you for heart disease.  

The impact of how heavy metal burden affects a person depends on their sensitivity. Type O blood patients seem to provide few symptoms and these are the patients who take the least care of themselves because they “feel fine”.  “Feeling fine” does not necessarily reflect the truth which is why health checkups are important.  Areas of concern may be when you see elevations of cholesterol, dysfunction of blood sugar, mental confusion and fatigue.  For example, trace mineral depletion is caused by disruption of transport by heavy metals competing for receptor sites on transport proteins and metallothioneins and by binding sulhydryl groups on many enzymes.  This process may be so gradual, you may fail to recognize the onset of persistent fatigue, decreased mental acuity, or increased issues with metabolism, yet your doctor may not know how to test for these or why they might be important.  In contrast, the type A blood patient is very sensitive and notes many more symptoms because they tend to be more sensitive to their environment.

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www.mynetimpact.com/1153052

www.multipureusa.com/hwc

 

 

Antioxidants – The Powerful Trio – Fighting Diabetes ALC

Acetyl-l-Carnatine                               Part 3                    

 This product is derived from lysine and methionine and is synthesized in the liver and kidneys.  It is found in highest concentrations in tissues that use fatty acids such as skeletal and cardiac muscle as it helps fatty acid oxidation-the process of transport across the mitochondra membrane to allow for oxidation of fatty acids. 

Related to the chronic affect of diabetes and other chronic conditions:

*ALC works by preventing buildup of mayloid plaque that damages brain tissues and is emerging as a cause of cognitive disorders such as Alzheimer’s.

*ALC improves syntheses of neurotransmitters such as acetylcholine and uptake of choline. 

*ALC improves Alzheimer’s by helping to maintain brain energy production, phospholipid metabolism and acetylcoenzyme A levels-the later being used to re-synthesize acetylcholine.

*ALC helps maintain liver function essential for detoxification.

*ALC almost completely restores the age-dependent decline in oxygen consumption in the liver.

*ALC helps prevent hepatoxicity and increases survival during chemotherapy.

*ALC enhances detoxification of ethanol in the liver

*Promotes cellular energy production & simulates the release of acetylcholine and dopamine which promotes the growth of neuritis that facilitate communication among nerve cells in the brain. 

*ALC prevents a variety of structural changes to the aging brain from the hippocampus, prevents decreases in receptor site sensitivitity, and prevents loss of receptors in various areas over the brain.  Within sevens days of treatment with ALC increases in serotonin and dopamine output in rats is seen. 

*ALC in human trials improved nerve pain, nerve regeneration and sensory perceptions in patients with diabetes neuopathy.

*ALC studies show significant improvement in mild Alzheimer’s and cognitive impairment.

*ALC in randomized studtes was successfully used for Chonic Fatigue Syndrome and fatigue in MS

*ALC has proven itself in brain regeneration in animal and human brain cell studies. Together with the proven synergy between ALC in regrowing neuritis and dendrites-a vitally important supplement for the brain.

*Combined with uridine 5-monophosphate from phosphatidylcholine, the effects of nerve growth factor increases 100 times to regrow neuritis and dendrites because of the synergistic effect.  Uridine increases the release of dopamine in brains.  Phosphatidylcholine is the real dietary source of cytidine, a building block of the cell membrane component and signaling agent necessary for memory.  PC declines with age and a major contributor of memory loss.

 ALA, ALC (acetyl-l-carnitine) & carnosine help disorders of cognitive decline and to reduce cardiovascular disease when used together.

Center for Environmental Medicine

Antioxidants – The Powerful Trio – Fighting Diabetes – L-Carnosine

 

L- CARNOSINE            Part 2

Part 1              Alpha Lipoic Acid       
Part 3              Acetyl-l-Carnatine

n 1900 in Moscow, Gulevitsch and Amiradgibi isolated a new compound.  In 1994 Professor Steven Charles Gallant attention was drawn to an experiment and found that when l-carnosine was added to old human cells in a culture, it was able to rejuvenate the cells in such a way that they virtually matched young human cells.  In 1996 they began testing mice with amazing results.   L-Carnosine is a natural body product consisting of the amino acids Beta-alanine and L-histidine chemically bound to each other and is known scientifically as N-beta-alanyl-histidine.  It is found in high levels in nerve cells (neurons) and muscle cells (myocytes).  Levels are high when you are born and decreases with age.  L-Carnosine is the most effective anti-carbonylation agent yet discovered and helps to prevent skin collagen cross-linking which leads to loss of elasticity and wrinkles. (Carbonylation is a pathological step in the age-related degradation of the body’s proteins.) It may extend the functional life of the body’s key building blocks – cells, proteins, DNA and lipids.

Studies on the rejuvenating effects of L-Carnosine support it is free radicals protective, has rejuvenating ability of cells at end of the life cycle of dividing cells, restoring normal appearance and extending their cellular lifespan, ability to rejuvenate connective tissue cells and thus to expedite wound healing, has brain protective quality from plaque formation, helps prevent skin collagen cross-linking which leads to loss of elasticity and wrinkles and other issues.

For the intent of this article which is to address diabetes:

  • Carnosine works to lower glucose in cases of hyperglycemia.
  • Protein glycation or cross linking by excessive glucose damages nervous, vascular, kidney, retinal and other tissues and carnosine is an effect anti-glycating agent due to free radical scavenging abilities.
  • Works to suppress diabetes triggered increases in BP by reacting with small carbonyl compounds (aldehydes and keytones) which accumulate on proteins during aging.
  • Carnosine increases heart contractility by releasing calcium which enables the heart muscle to contract more efficiently through enhancement of calcium response in heart myocytes, in calcium-regulated proteins in cardiac muscles
  • Carnosine works to inhibit advanced glycation end-products (AGEs) which cross-links proteins, renders them insoluble, accumulates in protein plaques and leads to oxidation of neurons.
  • AGE inhibitors such as carnosine may work by chelating copper which is linked to brain disorders such as Alzheimer’s.

     Center for Environmental Medicine

Antioxidants – The Powerful Trio- Fighting Diabetes -ALA

 

Alpha Lipoic Acid                                          Part 1

Part 2          L- Carnosine                  to follow

Part 3          Acetyl-l-Carnatine    to follow 

A landmark study published in the Proceedings of the National Academy of Sciences in the 1950’s after Eli Lilly backed the discovery of the important synthetic amino acid alpha lipoic acid (ALA). (1)  The study shows the synergistic affects of ALA and acetyl-l-carnatine (ALC) to significantly combat aging & fight against diabetes (Asta Medica, a German pharmaceutical company has taken the lead more recently in the fight against diabetes neuropathy with ALA).  Today ALC and Carnosine have joined the ranks with ALA in the fight against diabetes.

 

  • Alpha lipioic acid (ALA)- increases glucose uptake from 40% (same as insulin)  to 300%
  • ALA works against insulin resistance by increasing the permeability of cell membranes which is decreased by hyperglycemia and prevents uptake of glucose.
  • Can prevent or slow neuropathy by 70%
  • Add Evening Primrose to improve blood flow and nerve function by lowering blood lipid risk factors.
  • ALA improved circulation to sciatic nerve (nerve function is reduced in neuropathy by impaired acetylcholine-mediated vascular relaxation and accumulation of SOD radicals.
  • ALA provides 85% protection against the 31% reduction in maximum endothelium relaxation to acetycholine that occurs in diabetes by improving nitric oxide levels, vasodilation and cervical ganglion blood flow.
  • ALA helps with cataracts.  About 60% of diabetes related cataracts can be prevented with ALA.
  • ALA works by recharging levels of the potent antioxidant glutathione which is essential for protecting the eye lens.
  • ALA works to prevent hypertension and protects against kidney and vascular injuries in rats by suppressing endothelin-1 (a substance produced in blood vessels that regulates their tone.)
  • ALA prevents hyperglycemia induced hypertension in rats by lowering free radical production and raising glutathione levels.
  • ALA suppressed in rats endothelin-1 (a substance produced in blood vessels that regulates their tone. 
  • ALA improves functions in the heart including oxygen uptake, ATP levels, cardiac output, pyruvate production, lactate accumulation and glucose and glycogen storage and breakdown, protects glutathione, control hydroxyl radicals which may account for anti-aging heart supporting function. 
  • Protects against reperfusion arrhythmias and lipid peroxidation
  • induced by ferrous ions and ascorbate.

      (1) www.bruceames.org/

Center for Environmental Medicine