Category Archives: Allergy

Obesity-Inflammation Related; Common Thread with Diseases Part 1

Obesity is thought to be a disease of inflammation, according to Michael Glade, Ph.D. 

I became acquainted with his work through a DVD given to me by NeuroScience.  We have use NeuroScience protocols with great success; a company that focuses on “Target Amino Acids” as a means to address healing of the adrenal gland and balance neurotransmitters for the treatment of many symptoms including anxiety, sleep maintenance and insomnia, depression, and memory loss.

Dr. Glade is a Certified Nutritional Specialist (CNS) with degrees from the Massachusetts Institute of Technology (MIT) and Cornell University and teaching and research experience at Rutgers University, the University of Maryland, Northwestern University and at the Nutrition Institute of the University of Bridgeport. [1] 

Dr. Glade contends that when a patient has obesity for 5 years or more, the cellular mechanism is disrupted and regulation is thrown off through nutritional and other influences.  Cancer, arthritis, allergy, digestive literature look for a common thread which is traditionally separate in peoples minds as separate diseases, but it is looking more and more that they are individual symptoms manifested in an individual similarly condition.  It starts with people who eat improperly and once the  condition of unregulated inflammation develops, then under that umbrella,  one could end up with all the listed above common disease.

Insulin resistance falls under this umbrella where something goes arye in the metabolism of glucose within muscle cells.  People don’t get better, they get worse.  It doesn’t cure or arrest with the use of any existing medications. Control of diabetes II and insulin is not cured or suppressed by any existing treatment medications.  The premise is that people who have insulin resistance will slowly but surely deteriorate.  Dr. Glade believes there is something missing in that model.  We are treating a blood level of insulin but not the disease. He suggests that something, possibly environmental is the missing piece.

Research suggest abdominal fat in the visceral organ (around organs inside) appears to be genetically different from much of the than other fat in the body.  It is the most insulin responsive part of the body. In insulin resistance patients, the insulin is not responsive on the muscle whereas the belly fat stores is over reactive and sucks the insulin up.  The degree of hypersensitive reflects as the more inflamed they become.  The more inflamed they are the more tendencies they have to over-store abdominal fat.

Insulin control in the pancreas is disturbed when the body is carrying a high amount of an inflammatory formed, abnormal cytokine molecules produced by the body so one part of the body can communicate with another part. Overreactions throughout the body because of  lifestyle, environment, diet, result in tissue not normally responsive, but will then activate due to an overexposure of inflammation.  This will force the organ to over-respond.  This condition is not well monitored or regulated in the body.  The blood has an almost unlimited capacity to carry these inflammatory molecules in the body.  This response is what needs to be brought under control and can only be accomplished by improved lifestyle, environmental factors, detoxification, and a healthy diet.

Part 2 will address what can be done about this dynamic problem.

[1]Dr. Michael Glade emphasizes  specific dietary plans and supplement protocols, especially in programs targeted at brain function, weight reduction, smoking cessation, and life extension for the terminally ill.  Dr. Glade lectures extensively across the US and Europe. Dr. Glade is a noted researcher who is deeply appreciated in the nutritional and scientific communities for providing a significant body of peer-reviewed substantiation for multiple health claims that have been approved by the FDA.


Food Allergy – Fixed and Aquired Part 1

Food allergy is believed to be the single most contributory factor of chronic disease and therefore warrants consideration when evaluating the patient.  Immune reactions to ingestants are much more complex than inhalants which tend to be a fixed allergy.  To the physician who understands the basic history and complex symptomology of food hypersensitivity, evaluation has a relevant place in determining cause of disease and impaired health in many patients. 

There are two major types of food allergy–fixed and cyclic. Other responses such as IgA and IgM will not be addressed here.  A fixed food allergy is designated as a IgE response that occurs each time the food is consumed regardless of how long it has been avoided and may include anaphylactic reaction.  A cyclic food allergy reaction is designated as IgG response and is related to frequency and quantity of the consumption of the offending food.  The initial consumption of the food gives a stimulus that the patient may enjoy and as this wears off, the undesirable symptoms begin.  Often the patient erroneously believes because they do not notice a symptom immediately, that the food is safe.  Theoretically food sensitivity or IgG response is the only allergic condition that can be perfectly controlled.  This is a bold statement without regard to conditions which can increase the sensitivity of the patient such as leaky gut syndrome. 

If symptoms improve with fasting for several days, then food allergy should be considered.  If symptoms worsen after a meal or symptoms are temporarily relieved after certain foods are consumed, food allergy should be considered.  And if cravings for favorite foods are common, food allergy should be considered.

A personal history should be taken to include home and occupational environment, all organ systems, and detailed history back to childhood.  Medications and supplement list should be compiled and alcohol intake should be evaluated.  The tests and methods to determine food sensitivities all have limitations but a combination of these tests often produces a treatment plan with good outcomes. 

Food Diary Evaluation:  A food diary of at least seven days, to include all fluids as well, is an important component to determine a correct diagnosis.

If a patient fasts for a period of four days, and most of the offending symptoms lessen or disappear, allergy is a contributor.  Additionally patients who tend to eat the same food over and over again, an irritation occurs in the gut resulting in small particles of the same crossing the gut barrier into the blood stream and are recognized as foreign bodies.  The immune system attacks them and sensitivity is developed, hence symptoms occur.  The diagnosis and treatment of food allergy can be accomplished by several different methods. 

Oral Food Challenge –

Food diary evaluation

Rotary diversified diet (Rinkel)

Elimination Diet  (Rowe)

4-day rotation food families (Randolph) – 74k

Commercial tests include RAST, IgE, IgG, Elisa and usually are not covered by insurance unless certain criteria are met meeting insurance standards such as eczema, psoriasis, autoimmune disease, neuropsychiatric issues, antihistimine failure, prednisone usage or under 4 years of age.

These tests along with diagnostic criteria will be discussed further in future articles as we continue to look at allergy and its impact on health.

Pesticides – Effects on Children

Our children seemingly have chronic exposure to pesticides from the womb to the grave.  Over a lifetime, with approximately 4.5 billion pounds of chemicals applied annually to crops, buildings and lawns in the United States, is it any wonder chronic illness in on the rise?  Reports of 50% intake of pesticide exposure occur within the first five years of life.
Additionally, some tests indicate vulnerability to pesticide up to three months before pregnancy and the first month after conception.  As if this isn’t enough, many pesticides detoxify through mother’s milk either as pesticides or their metabolites because the milks fat content causes the solubility of the toxin.  The developing brain and central nervous system have pronounced vulnerability to neurotoxicants such as lead, mercury, alcohol, other than pesticides and causes reason for concern.
While the overall use of pesticides decreased 17.2 % from 1979 to 1997,  that has little affect on children 6 years and younger who are much more susceptible to pesticide toxicity because they eat more, drink more and breathe more per body weight.  Children are physiologically different than adults because they grow rapidly requiring more energy Their activities of ground playing and water activities put them at greater risk for heavier exposure to pesticides in water, soil, and air.
Multiple pesticides may be present at the same time in mother’s milk and consequences may include altered social skills, decreased intelligence, and reproductive difficulties or failures.  Thyroid function in pregnant women is a critical determinate in IQ and some persistent pesticides such as polychlorinated biphenols and dioxins disrupt thyroid function.  In animal models studies have shown a variety of pesticies such as DDT/DDE, mirex, aldrin, dieldrin, atrazine, dieldrin, atrazine, hexachlorocyclobexane, toxaphene, alachlor, chlordane, vincloxolin and chlorphyrifos can interfere with estrogen androgen and thyroid receptors during critical periods of development.  Additionally, pesticides can affect neurotransmitter metabolism and electrophysiological actions. 

It’s important that we learn how to protect our kids and because certain pesticides such as DDT and DDE have a half-life of about 150 years in aquatic environments, seafood may be one of the easiest exposures to avoid.   Getting a child use to a good distilled fish oil high is DHA early in life is probably one of the best things you could do as it mobilizes many pesticide toxins out of the body but is also great for brain development, skin and liver function. 

Today there are sophisticated tests for pesticide residue of all kinds, which require a simple blood draw shipped to the laboratory.

Center for Environmental Medicine





Plastics-Protecting Your Children Against Allergy

The plastics industries insists that their products used in cooking and storage poses no risk to humans, yet a study by a Swedish and Danish team found a strong correlation between levels of phthalates and allergy symptoms in children.  Phthalates are the chemicals commonly used to soften plastic.

Research funded by the Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning, found higher levels of butyl benzyl phthalate in children suffering from a compared group of healthy ones.  They found a link between concentrations of butyl benzyl phthalate and the tendency to suffer from rhinitis (funny nose and eyes) and eczema.  Another phthalate was linked to asthma.

Source:  The Environmental Physician, Summer 2004

In Center for Environmental Medicine we commonly tests these levels in patients who show persistent symptoms of toxicity.  The test is a simple collection of urine after a diet restricted preparation for two days. Typically this test is not covered by insurance but by paying the fee directly to the laboratory, you can get a reduced price that is affordable. 

It takes 10 days for the test results and are then are reviewed with the doctor.  When levels are high, which is often, the following steps are taken.

1]  Restriction of exposure.  Absolutely no cooking in plastic containers, baggies, etc. 

2]  Nutritional supplements specific to the patient’s needs.

3]  Retesting.