Antioxidants – The Powerful Trio- Fighting Diabetes -ALA


Alpha Lipoic Acid                                          Part 1

Part 2          L- Carnosine                  to follow

Part 3          Acetyl-l-Carnatine    to follow 

A landmark study published in the Proceedings of the National Academy of Sciences in the 1950’s after Eli Lilly backed the discovery of the important synthetic amino acid alpha lipoic acid (ALA). (1)  The study shows the synergistic affects of ALA and acetyl-l-carnatine (ALC) to significantly combat aging & fight against diabetes (Asta Medica, a German pharmaceutical company has taken the lead more recently in the fight against diabetes neuropathy with ALA).  Today ALC and Carnosine have joined the ranks with ALA in the fight against diabetes.


  • Alpha lipioic acid (ALA)- increases glucose uptake from 40% (same as insulin)  to 300%
  • ALA works against insulin resistance by increasing the permeability of cell membranes which is decreased by hyperglycemia and prevents uptake of glucose.
  • Can prevent or slow neuropathy by 70%
  • Add Evening Primrose to improve blood flow and nerve function by lowering blood lipid risk factors.
  • ALA improved circulation to sciatic nerve (nerve function is reduced in neuropathy by impaired acetylcholine-mediated vascular relaxation and accumulation of SOD radicals.
  • ALA provides 85% protection against the 31% reduction in maximum endothelium relaxation to acetycholine that occurs in diabetes by improving nitric oxide levels, vasodilation and cervical ganglion blood flow.
  • ALA helps with cataracts.  About 60% of diabetes related cataracts can be prevented with ALA.
  • ALA works by recharging levels of the potent antioxidant glutathione which is essential for protecting the eye lens.
  • ALA works to prevent hypertension and protects against kidney and vascular injuries in rats by suppressing endothelin-1 (a substance produced in blood vessels that regulates their tone.)
  • ALA prevents hyperglycemia induced hypertension in rats by lowering free radical production and raising glutathione levels.
  • ALA suppressed in rats endothelin-1 (a substance produced in blood vessels that regulates their tone. 
  • ALA improves functions in the heart including oxygen uptake, ATP levels, cardiac output, pyruvate production, lactate accumulation and glucose and glycogen storage and breakdown, protects glutathione, control hydroxyl radicals which may account for anti-aging heart supporting function. 
  • Protects against reperfusion arrhythmias and lipid peroxidation
  • induced by ferrous ions and ascorbate.


Center for Environmental Medicine


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